Cryopreservation impairs cytotoxicity and migration of NK cells in 3-D tissue: Implications for cancer immunotherapy
C. Mark, T. Czerwinski, S. Roessner, A. Mainka, F. Hörsch, L. Heublein, A. Winterl, S. Sanokowski, S. Richter, N. Bauer, G. Schuler, B. Fabry, C. J. Voskens
This study shows that cryopreservation reduces NK cell cytotoxicity and motility in 3-D collagen gels, potentially explaining the failure of NK cell therapies for solid tumors.
bioRxiv · Oct 21, 2019 · PreprintImmunology