Author

N. Bauer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:Arabidopsis· 1 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:flow cytometry· 1

Frequent Co-Authors

S. Knapp· 2 shared A. C. Joerger· 1 shared A. Gonzalez Ortega-Villaizan· 1 shared A. Krapp· 1 shared A. Kumar· 1 shared A. Mainka· 1 shared A. Smolko· 1 shared A. Stolz· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersBiochemistry

S. Knapp

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The endophytic fungus Serendipita indica alters auxin distribution in Arabidopsis thaliana roots through alteration of auxin transport and conjugation to promote plant growth

A. Gonzalez Ortega-Villaizan, E. King, M. K. Patel, M. M. PEREZ ALONSO, S. S. Scholz, H. Sakakibara, T. Kiba, M. Kojima, Y. Takebayashi, P. Ramos, L. Morales-Quintana, S. Breitenbach, A. Smolko, B. Salopek-Sondi, N. Bauer, , S. Pollmann

This study identifies how the endophytic fungus Serendipita indica promotes Arabidopsis growth by altering auxin transport and conjugation through GH3 genes and PIN2 expression.

bioRxiv · Jan 23, 2024 · PreprintPlant Biology

Targeting LC3/GABARAP for degrader development and autophagy modulation

M. P. Schwalm, J. Dopfer, A. Kumar, F. A. Greco, N. Bauer, F. Loehr, J. Heering, S. Cano, S. Lechner, T. Hanke, I. Bekic, V. Morasch, D. Fearon, P. G. Marples, C. W. E. Tomlinson, , V. V. Rogov

The paper evaluates the druggability of LC3/GABARAP for autophagy modulators and identifies ligands that bind to the HP2 pocket of the LIR docking site.

bioRxiv · Oct 5, 2023 · PreprintBiochemistry

Development of potent dual BET/HDAC inhibitors via pharmacophore merging and structure-guided optimization

N. Bauer, D.-I. Balourdas, J. R. Schneider, X. Zhang, L. M. Berger, B.-T. Berger, N. A. Klopp, J. T. Siveke, S. Knapp, A. C. Joerger

This study develops potent dual BET/HDAC inhibitors through pharmacophore merging and structure-guided optimization, showing improved potency and efficacy in cancer cell models.

bioRxiv · Jul 18, 2023 · PreprintBiochemistry

Cryopreservation impairs cytotoxicity and migration of NK cells in 3-D tissue: Implications for cancer immunotherapy

C. Mark, T. Czerwinski, S. Roessner, A. Mainka, F. Hörsch, L. Heublein, A. Winterl, S. Sanokowski, S. Richter, N. Bauer, G. Schuler, B. Fabry, C. J. Voskens

This study shows that cryopreservation reduces NK cell cytotoxicity and motility in 3-D collagen gels, potentially explaining the failure of NK cell therapies for solid tumors.

bioRxiv · Oct 21, 2019 · PreprintImmunology