C. Mark

Remote sensing of emperor penguin abundance and breeding success

This paper develops a phenological model to predict emperor penguin breeding pairs and chicks from sparse satellite data, improving population monitoring in remote areas.

Fiber alignment in 3D collagen networks as a biophysical marker for cell contractility

This study uses fiber alignment and density in 3D collagen networks as a proxy for cell traction forces, validated in hepatic stellate cells and glioblastoma cell lines, and provides an open-source tool for drug screening.

Immune cells employ intermittent integrin-mediated traction forces for 3D migration

This study shows immune cells switch between amoeboid and contractile migration modes in dense matrices, using integrin-mediated forces to navigate steric hindrance.

Dynamic traction force measurements of migrating immune cells in 3D matrices

This study measures dynamic traction forces of migrating NK cells in 3D matrices and finds that force bursts increase with matrix stiffness to aid migration through constrictions.

Timelapse viability assay to detect division and death of primary multiple myeloma cells in response to drug treatments with single cell resolution

The paper develops tools to assess drug response in primary multiple myeloma cells with single-cell resolution, enabling functional analysis of therapy response in patient-derived samples.

Cryopreservation impairs cytotoxicity and migration of NK cells in 3-D tissue: Implications for cancer immunotherapy

This study shows that cryopreservation reduces NK cell cytotoxicity and motility in 3-D collagen gels, potentially explaining the failure of NK cell therapies for solid tumors.

Measurement of skeletal muscle fiber contractility with high-speed traction microscopy

This paper introduces a method to measure contractile forces and calcium dynamics in single muscle fibers using high-speed traction microscopy and applies it to mouse fibers.

Collective forces of tumor spheroids in three-dimensional biopolymer networks

This study quantifies collective contractile forces of tumor spheroids on 3D collagen networks, showing initial cell-level contractility and later matrix-guided forces.