PI 3-kinase isoform p110α mediated FOXO1 inactivation protects against aortic aneurysm formation
M. Vantler, M. Schorscher, E. M. Berghausen, M. Zierden, J. Spitzer, J. B. Moore, D. Wong, Z. Li, M. Wissmueller, L. Gnatzy-Feik, D. Unnersjoe-Jess, L.-M. A. Zimmermann, M. Grandoch, D. Mehrkens, M. Adam, , S. Rosenkranz
This study shows that p110α-mediated FOXO1 inactivation in smooth muscle cells prevents aortic aneurysm formation by maintaining vascular homeostasis and promoting reparative SMC phenotypes.
bioRxiv · Dec 1, 2022 · PreprintCell Biology