PI 3-kinase isoform p110α mediated FOXO1 inactivation protects against aortic aneurysm formation
M. Vantler, M. Schorscher, E. M. Berghausen…·S. Rosenkranz
This study shows that p110α-mediated FOXO1 inactivation in smooth muscle cells prevents aortic aneurysm formation by maintaining vascular homeostasis and promoting reparative SMC phenotypes.