The R1441C-LRRK2 mutation induces myeloid immune cell exhaustion in an age- and sex-dependent manner
R. Wallings, K. McFarland, H. Staley, N. Neighbarger, S. Schaake, N. Brueggemann, S. Zittel, T. Usnich, C. Klein, E. Sammler, M. G. Tansey
The R1441C-LRRK2 mutation leads to age-dependent immune cell exhaustion in macrophages, with sex-specific effects observed in mice and human patients.
bioRxiv · Oct 12, 2023Immunology