C. Klein

Large transient assemblies of Apaf1 constitute the apoptosome in cells

The paper shows that Apaf1 forms transient foci during apoptosis, which correspond to the apoptosome and regulate apoptosis progression.

The R1441C-LRRK2 mutation induces myeloid immune cell exhaustion in an age- and sex-dependent manner

The R1441C-LRRK2 mutation leads to age-dependent immune cell exhaustion in macrophages, with sex-specific effects observed in mice and human patients.

Low exposure to lithium does not induce nephrogenic diabetes insipidus but microcystic dilations of collecting ducts in a long-term rat model

This study shows that low lithium exposure in rats causes microcystic dilations of collecting ducts without inducing nephrogenic diabetes insipidus.

Endosome dysfunction leads to gain-of-function TLR7 and human lupus

This study shows that endosome dysfunction causes TLR7 gain-of-function and contributes to human lupus by disrupting TLR7 turnover and leading to self-reactivity.

Dogs and cats are less susceptible to the omicron variant of concern of SARS-CoV-2 - a field study

This study investigates the susceptibility of dogs and cats to the omicron variant of SARS-CoV-2 by testing seropositivity in pets exposed to infected owners during the delta and omicron periods.

Humanized CAR T cells targeting p95HER2

This study develops CAR T cells targeting p95HER2, a tumor-specific antigen, showing efficacy against HER2-amplified tumors and metastases with reduced off-tumor effects.

The global rarity of intact coastal regions

The paper assesses global coastal regions' anthropogenic pressures by integrating human footprint and marine impact maps, finding that most are heavily impacted and protected areas are often under high pressure.

Human immunocompetent Organs-on-Chips platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies

The paper demonstrates that human immunocompetent Organs-on-Chips can predict safety liabilities of T-cell bispecific antibodies targeting tumor antigens.

Cross-Linking of T cell to B cell lymphoma by the T cell bispecific antibody CD20-TCB induces IFNγ/CXCL10-dependent peripheral T cell recruitment in humanized murine model.

This study investigates how CD20-TCB induces T cell-tumor synapses and recruitment in a humanized murine model of DLBCL, revealing a triple mechanism involving synapse formation, resident T cell proliferation, and peripheral T cell recruitment.

Maintenance of epithelial traits and resistance to mesenchymal reprogramming promote proliferation in metastatic breast cancer

This study shows that high EPCAM expression in metastatic breast cancer cells supports epithelial traits and plasticity, promoting metastatic outgrowth, while loss of epithelial traits inhibits it.

Induced aneuploidy disrupts MCF10A acini formation and CCND1 expression

This study shows that induced aneuploidy disrupts MCF10A acini formation and upregulates CCND1 expression through altered promoter-enhancer interactions.

The Relationship Between the Cervical Microbiome, HIV Status, and Pre-Cancerous Lesions

The study examines the cervical microbiome in Tanzanian women, finding higher bacterial richness in HIV-positive individuals and those with high-grade squamous intraepithelial lesions.

Active fluctuations modulate gene expression in mouse oocytes

The paper shows that nucleus positioning in mouse oocytes affects gene expression and chromatin dynamics through F-actin-mediated mechanical forces.