Intrinsically disordered regions in the transcription factor MYC:MAX modulate DNA binding via intramolecular interactions
S. Schuetz, C. Bergsdorf, S. Haenni-Holzinger, A. Lingel, M. Renatus, A. D. Gossert, W. Jahnke
This study identifies intramolecular interactions between intrinsically disordered regions and the DNA binding domain of MYC:MAX, showing they compete with DNA binding and slow complex formation.
bioRxiv · Jun 21, 2023Biophysics