Conformational landscape of the transcription factor ATF4 is dominated by disordered-mediated inter-domain coupling
U. Patel, S. Siang, D. Potoyan, J. Roche
This study investigates the structural basis of inter-domain interactions in ATF4, revealing that disorder-mediated coupling between transactivation and bZip domains shapes its conformational landscape.
bioRxiv · May 12, 2023 · PreprintBiophysics