Author

J. Roche

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Biochemistry· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein folding & dynamics· 5 Organism:human· 4 Approach:statistical model· 4 Assay:proteomics· 3 Approach:biophysical modeling· 2 Approach:deep learning· 2 Assay:protein structure· 2

Frequent Co-Authors

D. Potoyan· 2 shared U. Patel· 2 shared A. Bax· 1 shared A. G. Vos· 1 shared A. J. Baldwin· 1 shared A. Kumar· 1 shared A. L. Hansen· 1 shared A. L. Wadley· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersBiochemistry

D. Potoyan

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Thermodynamic Coupling of the tandem RRM domains of hnRNP A1 underlie its Pleiotropic RNA Binding Functions

J. D. Levengood, D. Potoyan, S. Penumutchu, A. Kumar, Y. Wang, A. L. Hansen, S. Kutluay, J. Roche, B. S. Tolbert

This study shows that thermodynamic coupling between tandem RRM domains of hnRNP A1 is essential for its allosteric RNA binding functions and stability under pressure.

bioRxiv · Aug 17, 2023 · PreprintBiochemistry

Evidence of Disrupted-in Schizophrenia 1 (DISC1) as an arsenic binding protein and implications regarding its role as a translational activator

M. Watanabe, T. M. Khu, G. Warren, J. Shin, C. E. Stewart, J. Roche

This study shows DISC1 binds arsenic via a C-terminal cysteine motif and suggests it acts as a sensor and translational modulator in the Akt/mTOR pathway.

bioRxiv · Jun 14, 2023 · PreprintBiophysics

Conformational landscape of the transcription factor ATF4 is dominated by disordered-mediated inter-domain coupling

U. Patel, S. Siang, D. Potoyan, J. Roche

This study investigates the structural basis of inter-domain interactions in ATF4, revealing that disorder-mediated coupling between transactivation and bZip domains shapes its conformational landscape.

bioRxiv · May 12, 2023 · PreprintBiophysics

Refining structural models of membrane proteins withdisordered domains in phospholipid nanodiscs

M. C. Pedersen, N. T. Johansen, J. Roche, M. Jaarvaa, S. Tornroth-Horsefield, L. Arleth

This study refines structural models of membrane proteins with disordered domains using small-angle x-ray scattering in nanodiscs and introduces new computational methods and software.

bioRxiv · Oct 28, 2022 · PreprintBiophysics

The intrinsically disordered cytoplasmic tail of a dendrite branching receptor uses two distinct mechanisms to regulate the actin cytoskeleton

D. A. Kramer, H. Y. Narvaez-Ortiz, U. Patel, R. Shi, K. Shen, B. J. Nolen, J. Roche, B. Chen

This study identifies two distinct mechanisms by which the intrinsically disordered cytoplasmic tail of HPO-30 regulates actin dynamics during dendrite branching in C. elegans.

bioRxiv · May 13, 2022Biochemistry

Working nights and lower leisure-time physical activity associate with chronic pain in Southern African truck drivers: a cross-sectional study

A. L. Wadley, S. Iacovides, J. Roche, K. Scheuermaier, W. F. Venter, A. G. Vos, S. T. Lalla-Edward

This study finds that working nights and lower leisure-time physical activity are linked to chronic pain in Southern African truck drivers, along with associations with sleep quality and depression.

bioRxiv · Sep 23, 2020Physiology

High-Accuracy Multiplexed SARS-CoV-2 Antibody Assay with Avidity and Saliva Capability on a Nano-Plasmonic Platform

T. Liu, J. Hsiung, S. Zhao, J. Kost, D. Sreedhar, K. Olson, D. Keare, J. Roche, C. V. Hanson, C. Press, J. Boggs, J. P. Rodriguez-Soto, J. G. Montoya, M. Tang, H. Dai

This paper develops a high-accuracy multiplexed SARS-CoV-2 antibody assay using a nano-plasmonic platform, showing high specificity and sensitivity in serum and saliva samples.

bioRxiv · Jun 16, 2020 · PreprintBiochemistry

Disorder mediated oligomerization of DISC1 proteins revealed by coarse-grained computer simulations.

J. Roche, D. A. Potoyan

This study uses coarse-grained simulations to show that conformational heterogeneity and structural disorder influence DISC1 oligomerization, with differences observed between full-length and truncated variants.

The Journal of Physical Chemistry B · Oct 15, 2019Peer-reviewedBiophysics

Local unfolding of the HSP27 monomer regulates chaperone activity

T. R. Alderson, J. Roche, H. Y. Gastall, I. Pritisanac, J. Ying, A. Bax, J. L. P. Benesch, A. J. Baldwin

This study shows that redox-induced monomerization of HSP27 enhances its chaperone activity but also increases aggregation risk, with mutations in an unstructured region linked to neuropathies.

bioRxiv · Jun 14, 2018Biophysics