GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy
A. Mukha, U. Kahya, A. Linge, O. Chen, S. Lock, V. Lukiyanchuk, S. Richter, T. C. Alves, M. Peitzsch, V. Telychko, S. Skvortsov, G. Negro, B. Aschenbrenner, I.-I. Skvortsova, P. Mirtschink, , A. Dubrovska
This study shows that glutamine catabolism via GLS regulates redox state, stemness, and autophagy in prostate cancer, affecting radiosensitivity and patient outcomes.
bioRxiv · Jan 7, 2021Cancer Biology