A home-cage, video monitoring-based mouse frailty index detects age-associated morbidity in the absence of handler-induced stress.
J. G. Ruby, P. Ylagan, A. Di Francesco, J. Zavala-Solorio, R. Keyser, O. Williams, S. Spock, W. Li, N. Vongtharangsy, S. Chatterjee, C. A. Sloan, C. Ledogar, V. Kuiper, J. Kite, M. Cosino, , E. M. Karlsson
This paper develops a digital frailty index using home-cage video monitoring in mice, showing it correlates with manual scores and age, reducing stress and labor.
bioRxiv · Jul 19, 2022 · PreprintAnimal Behavior & Cognition