S. Chatterjee

A trustworthy semantic knowledge network linking data-driven cell phenotypes to diseases and drugs

The paper develops NLM-CKN, a semantic knowledge network linking cell phenotypes to diseases and drugs using integrated data from 88 datasets.

Phosphoglucomutase A mediated regulation of carbon flux is essential for antibiotic and disease persistence in Mycobacterium tuberculosis

This study shows that phosphoglucomutase A (pgmA) is essential for Mycobacterium tuberculosis survival under nutrient-limiting conditions and disease persistence.

Network controllability analysis reveals the antiviral potential of Etravirine against Hepatitis E Virus infection

This study identifies CK1ε as an antiviral target for HEV and shows that Etravirine, an HIV drug, inhibits CK1ε to exhibit antiviral activity against HEV.

Arabidopsis CNL receptor SUT1 confers immunity in hydathodes against the vascular pathogen Xanthomonas campestris pv. campestris

This study identifies SUT1 as a novel immune receptor in Arabidopsis hydathodes that confers resistance to Xcc, effective during early infection but not in vascular tissues.

Controllable multi-halogenation of a non-native substrate by SyrB2 iron halogenase

This paper demonstrates how SyrB2 iron halogenase can controllably halogenate non-native substrates to produce mono-, di-, and tri-chlorinated products by adjusting cofactor loading and electron transfer.

Cross-correlation increases sampling in diffusion-based super-resolution optical fluctuation imaging

This paper demonstrates that cross-correlation improves sampling and reduces aliasing in diffusion-based super-resolution optical fluctuation imaging for nanoscale dynamics and structure analysis.

Remodeling Ca2+ dynamics by targeting a promising E-box containing G-quadruplex at ORAI1 promoter in triple-negative breast cancer.

The paper identifies a G-quadruplex in the ORAI1 promoter that regulates transcription and Ca2+ dynamics in triple-negative breast cancer.

Uncovering nick DNA binding by LIG1 at the single-molecule level

This study investigates how LIG1 binds to nick DNA at the single-molecule level, revealing specific and non-specific binding dynamics and the role of the N-terminal region in nick search.

Isolation and Characterization of a Halomonas Species for Non-Axenic Growth-Associated Production of Bio-Polyesters from Sustainable Feedstocks

The paper isolates and characterizes a Halomonas species capable of producing bio-polyesters from sustainable feedstocks under non-axenic conditions.

Conformational switch of a peptide provides a novel strategy to design peptide loaded porous organic polymer for Pyroptosis pathway mediated cancer therapy

This paper designs a peptide-loaded porous organic polymer that undergoes a conformational switch in cancer cells, triggering pyroptosis via membrane pore formation.

In Silico designed cell-penetrating anti-cancer peptide specifically inhibits VEGF-A expression

The paper designs in silico peptides that stabilize VEGF-A G-quadruplexes, reducing gene expression and inhibiting angiogenesis in cancer cells.

A meta-analysis of the gut microbiome in inflammatory bowel disease patients identifies disease-associated small molecules

This study identifies disease-associated small molecules from the gut microbiome of IBD patients using metagenomic analysis and synthetic biology.

ALTering cancer by triggering telomere replication stress through the stabilization of promoter G-quadruplex in SMARCAL1

This study shows that stabilizing G-quadruplex in SMARCAL1 promoter reduces its expression, increases replication stress, and promotes DNA damage in ALT-positive cancer cells, suggesting G4 stabilizers as potential therapeutics.

Ribosome Quality Control Mechanism Mitigates the Cytotoxic Impacts of Ribosome Collisions Induced by 5-Fluorouracil

This study shows that 5-Fluorouracil induces ribosome collisions, which are mitigated by the RQC mechanism through mTOR-dependent regulation of RQC factors.

Design and fabrication of flexible biodegradable microelectrode array for recording electrocorticography signals

This paper designs and fabricates a biodegradable microelectrode array for recording electrocorticography signals in rats, showing minimal tissue damage and potential for chronic brain activity monitoring.

Extremely oligotrophic and complex carbon degrading microaerobic bacteria from Arabian Sea oxygen minimum zone sediments

The paper isolates and characterizes aerobic bacteria from Arabian Sea sediments, showing their ability to degrade complex organic matter under low oxygen conditions and maintain populations in oligotrophic environments.

Metallo-protease Peptidase M84 from Bacillus altitudinis induces ROS dependent apoptosis in ovarian cancer cells by targeting PAR-1

This paper identifies Peptidase M84 from Bacillus altitudinis as an apoptosis inducer in ovarian cancer cells via PAR-1 mediated oxidative stress, showing anti-tumor effects in vitro and in vivo.

VapC12 ribonuclease toxin modulates host immune response during Mycobacterium tuberculosis infection

This study shows that the VapC12 toxin in Mycobacterium tuberculosis modulates host immune responses, promoting pathogen survival by altering T-cell and neutrophil responses.

Astroglia proliferate upon biogenesis of tunneling nanotubes and clearance of α-synuclein toxicities

This study shows that α-synuclein protofibrils induce tunneling nanotube biogenesis in astrocytes, which facilitates clearance of toxic aggregates and reversal of cellular senescence, leading to enhanced proliferation.

14K Prolactin Derived 14-Mer Antiangiogenic Peptide Targets Bradykinin-/Nitric Oxide-cGMP-Dependent Angiogenesis

This study identifies a novel 14-mer antiangiogenic peptide derived from prolactin that inhibits bradykinin- and eNOS-dependent angiogenesis, showing synergistic effects with Avastin in a colon cancer model.

Development and Analytical Evaluation of a Point-of-Care Electrochemical Biosensor for Rapid and Accurate SARS-CoV-2 Detection

This paper develops an electrochemical biosensor for rapid and accurate SARS-CoV-2 detection with high sensitivity and specificity.

Electrostatically regulated active site assembly governs reactivity in non-heme iron halogenases

This study investigates how anion and substrate binding cooperatively regulate reactivity in non-heme iron halogenases through electrostatic interactions in the active site.

Microtubule search-and-capture model evaluates the effect of chromosomal volume conservation on spindle assembly during mitosis

Cell state transition analysis identifies interventions that improve control of M. tuberculosis infection by susceptible macrophages

The paper identifies chemical perturbations that shift the transcriptional state of TB-susceptible macrophages toward TB-resistant cells, improving resistance to M. tuberculosis.

SARS-CoV-2 protein NSP2 enhances microRNA-mediated translational repression

This study shows that SARS-CoV-2 NSP2 enhances miRNA-mediated translational repression by interacting with Argonaute 2 and the GIGYF2 complex.

Atheroprone shear stress stimulates noxious endothelial extracellular vesicle uptake by MCAM and PECAM-1 cell adhesion molecules

This study investigates how atheroprone and atheroprotective shear stress affects endothelial extracellular vesicle (EV) release and uptake, finding that LSS increases EV uptake through adhesion molecules like MCAM and PECAM-1.

CLASPs stabilize the intermediate state between microtubule growth and catastrophe

This study shows CLASP1 stabilizes the intermediate state between microtubule growth and catastrophe by altering microtubule stability in a nucleotide-dependent manner.

Study of droplet generation in an E-shaped microchannel using two-phase level-set method

The paper uses numerical simulations to study droplet splitting in an E-junction microchannel using a two-phase level-set method.

Discovery, Synthesis, and Optimization of 1,2,4-Triazolyl Pyridines Targeting Mycobacterium tuberculosis

This paper discovers and optimizes a new series of 1,2,4-triazolyl pyridines that inhibit Mycobacterium tuberculosis growth with nanomolar activity and favorable pharmacokinetics.

Breast cancer progression and metastasis to lymph nodes reveals cancer cell plasticity and MHC class II-mediated immune regulation

This study identifies MHC class II expression in metastatic breast cancer cells and shows its role in immune evasion and tumor progression through IFN-gamma and JAK/STAT signaling.