MCB-613 exploits a collateral sensitivity in drug-resistant EGFR-mutant non-small cell lung cancer through covalent inhibition of KEAP1
C. F. Bassil, G. R. Anderson, B. Mayro, K. N. Askin, P. S. Winter, S. Gruber, T. M. Hall, J. P. Hoj, C. Cerda-Smith, H. M. Hutchinson, S. T. Killarney, K. R. Singleton, L. Qin, K. Jubien-Girard, C. Favreau, , K. C. Wood
The paper identifies MCB-613 as a compound that targets KEAP1 in EGFR inhibitor-resistant NSCLC cells, exploiting its selective essentiality through covalent inhibition.
bioRxiv · Jan 17, 2023 · PreprintCancer Biology