Cancer BiologybioRxivPreprint
MCB-613 exploits a collateral sensitivity in drug-resistant EGFR-mutant non-small cell lung cancer through covalent inhibition of KEAP1
C. F. Bassil, G. R. Anderson, B. Mayro…·K. C. Wood
The paper identifies MCB-613 as a compound that targets KEAP1 in EGFR inhibitor-resistant NSCLC cells, exploiting its selective essentiality through covalent inhibition.
DOI 10.1101/2023.01.17.524094