Dual targeting of GPX4 and TXNRD1 triggers eradication of AML cells through induction of apoptosis and ferroptosis
C. Favreau, C. Savy, M. Bourgoin, T. Botton, S. Bailly, F. Granger, C. Birck, M. Zerhouni, E. Kerreneur, A. Vigroux, J. Dussart-Gautheret, M.-L. Arcangeli, T. Cluzeau, A. Porterszman, S. Rocchi, , G. Robert
The paper identifies two compounds that target GPX4 and TXNRD1 to induce apoptosis and ferroptosis in AML cells, effectively eradicating malignant cells while sparing normal hematopoietic cells.
bioRxiv · Apr 3, 2024 · PreprintBiochemistry