Author

A. Puissant

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:genetic perturbation / CRISPR· 2 Organism:multiple species· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

V. LLAURENS· 2 shared A. Chotard· 1 shared A. Conway· 1 shared A. L. Robichaud· 1 shared A. M. Pendergast· 1 shared A. Petit· 1 shared A. R. Martin· 1 shared A. Su· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersEvolutionary Biology

V. LLAURENS

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Author profile →

5 papers

Recent·Most cited

Convergence in sympatric swallowtail butterflies reveals ecological interactions as a key driver of worldwide trait diversification.

A. Puissant, A. Chotard, F. L. Condamine, V. LLAURENS

This study shows sympatry promotes convergence in swallowtail butterfly wing color patterns, with stronger effects on females, highlighting ecological interactions' role in trait diversification.

bioRxiv · Feb 24, 2023Evolutionary Biology

MCB-613 exploits a collateral sensitivity in drug-resistant EGFR-mutant non-small cell lung cancer through covalent inhibition of KEAP1

C. F. Bassil, G. R. Anderson, B. Mayro, K. N. Askin, P. S. Winter, S. Gruber, T. M. Hall, J. P. Hoj, C. Cerda-Smith, H. M. Hutchinson, S. T. Killarney, K. R. Singleton, L. Qin, K. Jubien-Girard, C. Favreau, , K. C. Wood

The paper identifies MCB-613 as a compound that targets KEAP1 in EGFR inhibitor-resistant NSCLC cells, exploiting its selective essentiality through covalent inhibition.

bioRxiv · Jan 17, 2023 · PreprintCancer Biology

Convergence in sympatry: evolution of blue-banded wing pattern in Morpho butterflies

V. LLAURENS, Y. Le Poul, A. Puissant, C. Nous, P. Blandin, V. Debat

The paper tests if species interactions drive convergence in wing patterns among sympatric Morpho butterflies by comparing phenotypic distances in sympatric and allopatric populations.

bioRxiv · May 13, 2020Evolutionary Biology

Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy.

Y. Pikman, N. Ocasio-Martinez, G. Alexe, S. Kitara, F. F. Diehl, A. L. Robichaud, A. Conway, A. Su, J. Qi, G. Roti, C. A. Lewis, A. Puissant, M. G. Vander Heiden, K. Stegmaier

This study identifies SHMT1 and SHMT2 as therapeutic targets in T-ALL by showing their inhibition impairs leukemia progression and is effective despite methotrexate resistance.

bioRxiv · Feb 6, 2020Cancer Biology

Screening of clustered regulatory elements reveals functional cooperating dependencies in Leukemia.

S. Benbarche, C. K. Lopez, E. Salataj, C. Thirant, M.-C. Laiguillon, Z. Aid, S. Lecourt, M. Antonini, B. Pardieu, A. Petit, A. Puissant, J. Chaumeil, T. Mercher, C. Lobry

The paper identifies co-regulated genes in leukemia using CRISPRi screening of super-enhancer regions, showing that combined inhibition of KIT and PDGFRA synergizes to impair leukemia cell growth.

bioRxiv · Jun 24, 2019 · PreprintCancer Biology