Multi-omic analysis of subtype evolution and heterogeneity in high-grade serous ovarian carcinoma
L. Geistlinger, S. Oh, M. Ramos, L. Schiffer, R. LaRue, C. Henzler, S. Munro, C. Daughters, A. C. Nelson, B. Winterhoff, Z. Chang, S. Talukda, M. Shetty, S. Mullany, M. Morgan, , L. Waldron
This paper investigates the evolution and heterogeneity of high-grade serous ovarian carcinoma using multi-omic analysis, finding that subtypes emerge later in tumor development and are not discrete but rather part of a continuous spectrum.
bioRxiv · Jun 12, 2020Cancer Biology