M. Morgan

Application of chimeric antigens to paper-based diagnostics for detection of West Nile virus infections of Crocodylus porosus: a novel animal test case

The paper develops a lateral flow assay using chimeric antigens to detect West Nile virus seroconversion in crocodiles, achieving 100% sensitivity and specificity.

DERIVATION OF ELEPHANT INDUCED PLURIPOTENT STEM CELLS

This paper reports the first derivation of elephant induced pluripotent stem cells (emiPSCs) using a modified reprogramming protocol that inhibits TP53 expansion genes.

Ubiquitinated histone H2B as gatekeeper of the nucleosome acidic patch

This study reveals that H2BK120ub blocks the nucleosome acidic patch, preventing protein binding, while H2AK119ub does not, highlighting distinct roles of these ubiquitinations in chromatin regulation.

A multi-organ map of the human immune system across age, sex and ethnicity

The paper creates a comprehensive immune system map across age, sex, and ethnicity using single-cell RNA sequencing data, revealing immune ageing patterns and ethnic diversity in immune checkpoints.

Structural and regulatory insights into the glideosome-associated connector from Toxoplasma gondii

This study presents the crystal structure of Toxoplasma gondii GAC and proposes a multi-conformational model for its assembly in the glideosome.

MOV10 facilitates messenger RNA decay in an N6-methyladenosine (m6A) dependent manner to maintain the mouse embryonic stem cells state

The paper identifies MOV10 as a new m6A-reader that facilitates mRNA decay via m6A to regulate the WNT/β-CATENIN pathway and maintain mouse embryonic stem cell state.

3D matrix adhesion composition facilitates nuclear force coupling to drive invasive cell migration

This study identifies a 3D matrix adhesion complex involving β-PIX and Myo18A that drives invasive cell migration by coupling nuclear force transmission to protrusion dynamics.

Cells of the human intestinal tract mapped across space and time

The paper maps human intestinal cell lineages across development and disease, identifying new cell types and functions related to inflammation and immunity.

Multi-omic analysis of subtype evolution and heterogeneity in high-grade serous ovarian carcinoma

This paper investigates the evolution and heterogeneity of high-grade serous ovarian carcinoma using multi-omic analysis, finding that subtypes emerge later in tumor development and are not discrete but rather part of a continuous spectrum.

Tumor-infiltrating nerves create an electro-physiologically active microenvironment and contribute to treatment resistance

The paper shows that tumor-infiltrating nerves contribute to treatment resistance and that chemotherapy increases tumor innervation.

DNA Thermo-Protection Facilitates Whole Genome Sequencing of Mycobacteria Direct from Clinical Samples by the Nanopore Platform

This paper develops a thermo-protection buffer to enable direct whole genome sequencing of Mycobacteria from clinical samples using Nanopore technology, achieving high coverage at low bacterial concentrations.

A Single Nucleotide Polymorphism assay sheds light on the extent and distribution of genetic diversity, population structure and functional basis of key traits in cultivated North American Cannabis

The paper uses SNP markers to analyze genetic diversity and population structure in North American Cannabis, identifying clusters linked to cannabinoid profiles and traits.

Reconciling the potentially irreconcilable? Genotypic and phenotypic amoxicillin-clavulanate resistance in Escherichia coli

This study shows that amoxicillin-clavulanate resistance in E. coli is quantitative, not binary, and that WGS-based predictions outperform traditional phenotyping methods.

Metagenomic Nanopore sequencing of influenza virus direct from clinical respiratory samples

This study uses metagenomic Nanopore sequencing to detect influenza virus in clinical respiratory samples, achieving high sensitivity and complete genome sequencing.

MinION Nanopore Sequencing of Multiple Displacement Amplified Mycobacteria DNA Direct from Sputum

This study evaluates the effectiveness of multiple displacement amplification followed by MinION sequencing for detecting Mycobacteria DNA in sputum samples.

Whole genome sequencing for predicting clarithromycin resistance in Mycobacterium abscessus

This study uses whole genome sequencing to predict clarithromycin resistance in Mycobacterium abscessus by identifying known and novel resistance-determining mutations.