Author

L. Schiffer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

W. Arlt· 3 shared A. E. Taylor· 2 shared K.-H. Storbeck· 2 shared A. Bossey· 1 shared A. C. Nelson· 1 shared A. Freeman· 1 shared A. J. Sinclair· 1 shared A. Tiganescu· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiochemistry

W. Arlt

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Author profile →

4 papers

Recent·Most cited

Inhibition of the glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 drives concurrent 11-oxygenated androgen excess

L. Schiffer, I. Oestlund, J. Snoep, L. C. Gilligan, A. E. Taylor, A. J. Sinclair, R. Singhal, A. Freeman, R. Ajjan, A. Tiganescu, W. Arlt, K.-H. Storbeck

This study shows that inhibiting HSD11B1 increases 11-ketotestosterone levels in adipose tissue and circulation, potentially offsetting benefits of reduced glucocorticoid activation in women.

bioRxiv · Jun 5, 2023Biochemistry

Peripheral blood mononuclear cells preferentially activate 11-oxygenated androgens

L. Schiffer, A. Bossey, A. E. Taylor, I. Akerman, D. Scheel-Toellner, K.-H. Storbeck, W. Arlt

The paper shows human PBMCs preferentially activate 11-oxygenated androgens over classic androgens, with AKR1C3 in natural killer cells driving this conversion, and delayed sample processing increases serum 11KT levels.

bioRxiv · Sep 8, 2020Biochemistry

Multi-omic analysis of subtype evolution and heterogeneity in high-grade serous ovarian carcinoma

L. Geistlinger, S. Oh, M. Ramos, L. Schiffer, R. LaRue, C. Henzler, S. Munro, C. Daughters, A. C. Nelson, B. Winterhoff, Z. Chang, S. Talukda, M. Shetty, S. Mullany, M. Morgan, , L. Waldron

This paper investigates the evolution and heterogeneity of high-grade serous ovarian carcinoma using multi-omic analysis, finding that subtypes emerge later in tumor development and are not discrete but rather part of a continuous spectrum.

bioRxiv · Jun 12, 2020Cancer Biology

Testosterone enhances GLP-1 efficacy at the plasma membrane and endosomes to augment insulin secretion in male pancreatic β cells

W. Xu, F. Ashford, S. Bitsi, L. Schiffer, F. Qadir, W. Arlt, A. Tomas, D. Hodson, F. Mauvais-Jarvis

This paper shows testosterone enhances GLP-1's ability to increase insulin secretion in male β cells by boosting cAMP production at the plasma membrane and endosomes.

bioRxiv · May 12, 2020 · PreprintPhysiology