S. Oh

Opto-Myomatrix: μLED integrated microelectrode arrays for optogenetic activation and electrical recording in muscle tissue

This paper introduces Opto-Myomatrix, a device for optogenetic muscle activation and EMG recording, achieving high optical output and low electrode impedance.

Recruitment of CTCF to the SIRT1 promoter after Oxidative Stress mediates Cardioprotective Transcription

The paper shows that phosphorylated CTCF binds the SIRT1 promoter under oxidative stress, activating a cardioprotective transcriptional program in cardiomyocytes.

Physiological Processing of Aversiveness in the Mind's Ear: Comparing Audiovisual, Auditory and Imagined Auditory Affective Stimuli

The paper compares physiological responses to aversive and nonaversive audiovisual, auditory, and imagined auditory stimuli, finding consistent EMGc differentiation across modalities.

Multiomic Profiling Reveals Metabolic Alterations Mediating Aberrant Platelet Activity and Inflammation in Myeloproliferative Neoplasms

This study identifies metabolic alterations in MPN platelets, showing that alpha-ketoglutarate supplementation reduces hyperreactivity and inflammation.

Sequential genetic, epigenetic alterations in human pluripotent stem cells for recurrent abnormality

The paper investigates genetic and epigenetic changes in human pluripotent stem cells during in vitro culture and identifies 20q11.21 copy number gain and epigenetic modifications as key factors in inducing culture-adapted phenotypes.

Aberrant Wnt activation in recurrent genetically variant human pluripotent stem cells impairs cardiomyocyte differentiation and phenotype

This study shows that genetic variants in human pluripotent stem cells, specifically gains of chromosome 1q, impair cardiomyocyte differentiation and phenotype through aberrant Wnt activation.

Membrane potential mediates the cellular response to mechanical pressure

This study shows that membrane potential mediates cellular responses to mechanical pressure by regulating cell growth, proliferation, and elimination through Hippo and MAPK pathways.

TBK1 is ubiquitinated by TRIM5alpha to assemble mitophagy machinery

The paper shows TRIM5 ubiquitinates TBK1 to assemble mitophagy machinery on damaged mitochondria, essential for both Parkin-dependent and independent mitophagy.

The 21-base pair deletion mutant Calpain 3 does not inhibit wild-type Calpain 3 activity

This study investigates whether a 21-bp deletion mutant of Calpain 3 inhibits wild-type Calpain 3 activity and causes dominant toxicity in cell culture and Drosophila models, finding no inhibition of wild-type activity.

A compact, ultrahigh-density headstage with high-fidelity hybrid integration for large-scale deep-brain opto-electrophysiology

This paper introduces a high-channel-count optogenetic system for deep-brain studies, achieving high spatial resolution in recording and stimulation with unprecedented channel density.

Bacterial cell wall biosynthesis is controlled by growth rate dependent modulation of turgor pressure in E. coli

This study shows that turgor pressure in E. coli increases with growth rate and directly controls cell wall biosynthesis rate.

Mesoscale DNA Features Impact APOBEC3A and APOBEC3B Deaminase Activity and Shape Tumor Mutational Landscapes

This study identifies how mesoscale DNA features influence APOBEC3A and APOBEC3B deaminase activity and their impact on tumor mutational landscapes.

Scalable Mesenchymal Stem Cells Enrichment from Bone Marrow Aspirate using Deterministic Lateral Displacement (DLD) Microfluidics Sorting

This paper develops a microfluidic method to isolate mesenchymal stem cells from bone marrow aspirate more efficiently than centrifugation.

DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression

This study identifies DUSP6 as a driver of leukemic progression and resistance to JAK2 inhibition in MPNs, highlighting the DUSP6-RSK1 axis as a therapeutic target.

Blocking necroptosis reduces inflammation and tumor incidence in a mouse model of diet-induced hepatocellular carcinoma

Cryo-EM structure of a RAS/RAF recruitment complex

The paper presents cryo-EM structures of a KRAS/BRAF/MEK1/14-3-3 complex, showing KRAS binding to BRAF's Ras-binding domain without activating it, suggesting stabilization of a pre-activation intermediate as a therapeutic target.

Combination therapy with nirmatrelvir and molnupiravir improves the survival of SARS-CoV-2 infected mice

This paper evaluates combination antiviral therapies in SARS-CoV-2 infected mice, finding that nirmatrelvir and molnupiravir together significantly improve survival compared to monotherapies.

Distinct subpopulations of DN1 thymocytes exhibit preferential γδ T lineage potential

This study identifies distinct DN1 thymocyte subpopulations with preferential γδ T lineage potential using scRNA-seq in mice.

Rapid and Efficient BAC Recombineering: Gain & Loss Screening System

This paper introduces a gain & loss screening system for BAC recombineering that improves accuracy and reduces the time required to identify correct clones.

The energy requirements of ion homeostasis determine the lifespan of starving bacteria

This study identifies ion homeostasis as a key determinant of bacterial lifespan during starvation, showing that reducing its energetic cost extends survival.

Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K+ channel TMEM175

The paper investigates the ion selectivity mechanism of TMEM175, showing that its unique hydrophobic constriction and electrostatic field enable K+ selectivity without a canonical filter.

Protein and Lipid Mass Concentration Measurement in Tissues by Stimulated Raman Scattering Microscopy

The paper introduces NoRI, a SRS microscopy method to measure protein, lipid, and water concentrations in tissues, showing cell-specific variations and disease-related changes in Alzheimer's models.

Escherichia coli Cryptic Prophages Sense Nutrients to Control Persister Cell Resuscitation

The paper shows that cryptic prophages in E. coli regulate phosphate uptake to control persister cell resuscitation, preventing premature resuscitation in nutrient-poor conditions.

Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates

This study shows that 5-OP-RU treatment of M. tuberculosis-infected rhesus macaques leads to MAIT cell dysfunction rather than expansion, with upregulated PD-1 and loss of cytokine production.

APOBEC3A drives acquired resistance to targeted therapies in non-small cell lung cancer

This study shows that APOBEC3A mutagenesis driven by targeted therapies promotes drug resistance in non-small cell lung cancer.

Yeast Nuak1 phosphorylates histone H3 threonine 11 in low glucose stress conditions by the cooperation of AMPK and CK2 signaling

The paper identifies Tda1 as the kinase responsible for H3pT11 phosphorylation under low glucose stress, showing its regulation by AMPK and CK2 signaling in yeast.

Plant NLR targets P-type ATPase for executing plasma membrane depolarization leading to calcium influx and cell death

The paper shows that the plant NLR CCA309 targets P-type ATPase to cause membrane depolarization, calcium influx, and cell death during hypersensitive response.

Multi-omic analysis of subtype evolution and heterogeneity in high-grade serous ovarian carcinoma

This paper investigates the evolution and heterogeneity of high-grade serous ovarian carcinoma using multi-omic analysis, finding that subtypes emerge later in tumor development and are not discrete but rather part of a continuous spectrum.

The plasticity of the pyruvate dehydrogenase complex confers a labile structure that is associated with its catalytic activity

This study shows that the pyruvate dehydrogenase complex (PDC) is salt-labile and structurally variable, with activity affected by ionic strength.

Genome-wide functional analysis of hot pepper immune receptors reveals an autonomous NLR cluster in seed plants

This study identifies an autonomous NLR cluster in seed plants through functional analysis of hot pepper immune receptors, revealing conserved autoactive NLRs that trigger cell death independently of helper NLRs.