Synergistic effects of PARP inhibitors by Schlafen 11 and BRCA2-deficiency through accumulation of single-strand DNA gaps behind a fork
H. Onji, S. Tate, T. Sakaue, N. Onishi, T. Matsumoto, T. Sugiyama, S. Higashiyama, J. Murai
This paper shows that SLFN11 and BRCA2-deficiency together increase PARP inhibitor sensitivity by enhancing ssDNA gap accumulation behind replication forks.
bioRxiv · Jun 28, 2023 · PreprintCancer Biology