Author

J. Murai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

S. Higashiyama· 2 shared A. Ueda· 1 shared A. Vajdi Hoojghan· 1 shared C. Noyes· 1 shared C. Takahashi· 1 shared D. Barbie· 1 shared D. Larocca· 1 shared D. Xu· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCancer Biology

S. Higashiyama

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Author profile →

4 papers

Recent·Most cited

Clonal and Scalable Endothelial Progenitor Cell Lines from Human Pluripotent Stem Cells

J. Lee, H. Sterberg, P. A. Bignone, J. Murai, N. N. Malik, M. D. West, D. Larocca

This study derives and characterizes clonal endothelial progenitor cell lines from human embryonic stem cells, showing their scalability and functional similarity to adult endothelial cells.

bioRxiv · Aug 19, 2023 · PreprintCell Biology

Synergistic effects of PARP inhibitors by Schlafen 11 and BRCA2-deficiency through accumulation of single-strand DNA gaps behind a fork

H. Onji, S. Tate, T. Sakaue, N. Onishi, T. Matsumoto, T. Sugiyama, S. Higashiyama, J. Murai

This paper shows that SLFN11 and BRCA2-deficiency together increase PARP inhibitor sensitivity by enhancing ssDNA gap accumulation behind replication forks.

bioRxiv · Jun 28, 2023 · PreprintCancer Biology

Metabolic clogging of mannose triggers genomic instability via dNTP loss in human cancer cells

Y. Harada, Y. Mizote, T. Suzuki, M. Nishida, T. Hiratsuka, A. Ueda, Y. Imagawa, K. Maeda, Y. Ohkawa, J. Murai, H. H. Freeze, E. Miyoshi, S. Higashiyama, H. Udono, N. Dohmae, , N. Taniguchi

This study shows that excess mannose causes dNTP depletion, leading to genomic instability and enhanced sensitivity to chemotherapy in cancer cells.

bioRxiv · Oct 17, 2022Cancer Biology

The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells

C. Noyes, S. Kitajima, F. Li, Y. Suita, S. Miriyala, S. Isaac, N. Ahsan, E. Knelson, A. Vajdi Hoojghan, T. Tani, T. Thai, D. Xu, J. Murai, N. Tapinos, C. Takahashi, , M. Yajima

This study shows DDX4, a germline factor, enhances chemoresistance and motility in SCLC cells by altering metabolism and EMT-like features.

bioRxiv · Apr 22, 2022Cancer Biology