M. Ralser

An INS-1 beta-cell proteome highlights the role of fatty acid biosynthesis in glucose-stimulated insulin secretion

This study uses proteomics to analyze glucose-stimulated insulin secretion in rat beta cells, finding that fatty acid metabolism plays a key role in the process.

Tyrosine halogenation converts α-defensins into potent immunomodulators

The paper identifies that tyrosine halogenation of α-defensins by hypohalous acids converts them into immunomodulatory mediators, revealing a novel oxidative mechanism in neutrophil function.

The amino acid sequence determines protein abundance through its conformational stability and reduced synthesis cost.

This study shows that amino acid sequences determine protein abundance by affecting conformational stability and synthesis cost, using deep learning and yeast experiments.

Speedy-PASEF: Analytical flow rate chromatography and trapped ion mobility for deep high-throughput proteomics

Speedy-PASEF enables fast, high-quality proteomic analysis using moderate sample amounts, demonstrating its utility in studying COVID-19 plasma proteomes.

Slice-PASEF: Maximising Ion Utilisation in LC-MS Proteomics

Slice-PASEF improves tandem MS sensitivity for low-sample proteomics, enabling applications like single-cell proteomics and drug screens.

High-throughput proteomics of nanogram-scale samples with Zeno SWATH DIA

This paper introduces Zeno SWATH, a high-throughput proteomics method that improves protein identification and quantification in small sample amounts using fast chromatography.

Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan

The paper shows that metabolite exchange between cells extends lifespan in yeast by creating a pro-survival metabolic environment.

m6A reader Pho92 is recruited co-transcriptionally and couples translation efficacy to mRNA decay to promote meiotic fitness in yeast

SIGNR1 promotes immune dysfunction in systemic candidiasis by modulating neutrophil lifespan via T cell-derived histones and G-CSF

This study identifies SIGNR1's role in promoting immune dysfunction during systemic candidiasis by modulating neutrophil lifespan through T cell-derived histones and G-CSF.

Longitudinal omics in Syrian hamsters integrated with human data unravel complexity of moderate immune responses to SARS-CoV-2

The paper integrates longitudinal omics data from Syrian hamsters with human data to understand immune responses to SARS-CoV-2, identifying key cellular and molecular mechanisms.

Amino acids whose intracellular levels change most during aging alter chronological lifespan of fission yeast

The paper identifies amino acids whose intracellular levels change with aging in fission yeast and shows their impact on chronological lifespan.

Single amino acid-promoted reactions link a non-enzymatic chemical network to the early evolution of enzymatic pentose phosphate pathway

This paper shows how single amino acids can enhance non-enzymatic reactions similar to the pentose phosphate pathway, suggesting a stepwise evolution from environmental chemical networks to enzymatic metabolism.

A lncRNA/Lin28/Let7 Axis Coupled To DNA Methylation Fine Tunes The Dynamics Of A Cell State Transition

The paper identifies a lncRNA/miRNA/DNA methylation axis that regulates the timing of stem cell state transition from naive pluripotency.