Cell BiologyInvestigative Opthalmology & Visual SciencePeer-reviewed
FORMATION OF LIPOFUSCIN-LIKE AUTOFLUORESCENT GRANULES IN THE RETINAL PIGMENT EPITHELIUM REQUIRES LYSOSOME DYSFUNCTION
C. Escrevente, A. S. Falcao, M. J. Hall…·M. C. Seabra
This study shows that lysosomal dysfunction leads to incomplete degradation of photoreceptor outer segments and accumulation of autofluorescent granules in RPE cells.