The NLRP3/eIF2 axis drives cell cycle progression in acute myeloid leukemia
M. Luciano, C. Blöchl, J. Vetter, L. Urwanisch, T. Neuper, D. P. Elmer, R. Bauer, H.-H. Dang, H. Strandt, D. Neureiter, P. Krenn, S. Tesanovic, S. Rieser, O. Bergsleitner, L. Zell, , J. Horejs-Hoeck
This study shows that inhibiting the NLRP3 inflammasome reduces AML cell proliferation by promoting eIF2 phosphorylation and cell cycle arrest.
bioRxiv · Jun 25, 2021 · PreprintImmunology