R. Bauer

The stress of carrying CRISPR-Cas

This study investigates the CRISPR-Cas system in Streptococcus anginosus, finding that it imposes metabolic and fitness costs, impairing stress response and potentially explaining its low prevalence in this species.

Low-cost 3D printed lenses for brightfield and fluorescence microscopy

The paper presents low-cost 3D printed lenses for brightfield and fluorescence microscopy, demonstrating sub-cellular resolution comparable to commercial optics.

Printing, Characterising, and Assessing Transparent 3D Printed Lenses for Optical Imaging

This study develops a low-cost method to produce high-quality 3D printed lenses comparable to commercial glass lenses for optical imaging applications.

NAIP-NLRC4 Inflammasome Activation in Tuft Cells Activates a PGD2-ILC3 Signaling Circuit that Protects Against Enteric Infection.

This study shows that NAIP-NLRC4 inflammasome activation in tuft cells releases PGD2, which signals to ILC3s to enhance antibacterial defenses against Salmonella Typhimurium.

Tocilizumab treatment leads to early resolution of lymphopenia and myeloid dysregulation in patients hospitalized with COVID-19

Miniaturised structured illumination microscopy using two 3-axis MEMS micromirrors

This paper develops a compact structured illumination microscope using MEMS micromirrors to achieve improved lateral resolution in fluorescent samples.

Salmonella Typhimurium induces NAIP/NLRC4- and NLRP3/ASC-independent, caspase-1/4-dependent inflammasome activation in human intestinal epithelial cells

This study shows that human intestinal epithelial cells use caspase-1/4-dependent inflammasomes, not NAIP/NLRC4 or NLRP3/ASC, to respond to Salmonella Typhimurium.

Angicin, a novel bacteriocin of Streptococcus anginosus

This paper identifies Angicin, a novel bacteriocin from Streptococcus anginosus, which exhibits broad antimicrobial activity and stability under various conditions.

The HDL particle composition determines its anti-tumor activity in pancreatic cancer

This study shows that HDL particle composition affects its ability to remove cholesterol from pancreatic cancer cells, reducing tumor growth and increasing apoptosis.

The NLRP3/eIF2 axis drives cell cycle progression in acute myeloid leukemia

This study shows that inhibiting the NLRP3 inflammasome reduces AML cell proliferation by promoting eIF2 phosphorylation and cell cycle arrest.

Tuneable wide-field illumination and single-molecule photoswitching with a single MEMS mirror

This paper introduces a MEMS mirror for tunable wide-field illumination in SMLM, enabling consistent metrics and benchmarking of illumination schemes through single-molecule photoswitching.

MEMS enabled miniaturized light-sheet microscopy with all optical control

This paper describes a compact, cost-effective light-sheet microscopy system using MEMS scanners and tunable lenses for biomedical imaging.

Laser-facilitated epicutaneous immunotherapy with hypoallergenic beta-glucan neoglycoconjugates suppresses lung inflammation and avoids local side effects in a mouse model of allergic asthma

This study shows that LamOVA, a hypoallergenic beta-glucan neoglycoconjugate, suppresses lung inflammation and reduces side effects in a mouse asthma model when delivered via laser-facilitated epicutaneous immunotherapy.

Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion

This study shows that myeloid Trib1 promotes early atherosclerosis by enhancing foam cell formation through increased lipid uptake and OLR1 expression.