Cancer BiologybioRxivPreprint
Oncogenic GLI1 and STAT1/3 activation drives immunosuppressive tryptophan/kynurenine metabolism via synergistic induction of IDO1 in skin cancer cells
D. P. Elmer, V. Strobl, G. Stockmaier…·F. Aberger
This study identifies IDO1-kynurenine pathway activation as a novel mechanism by which HH-IL6 and GLI-STAT signaling promote immunosuppression in skin cancer, suggesting combination therapy targeting these pathways.
DOI 10.1101/2020.05.04.074757