MUC17 is an essential small intestinal glycocalyx component that is disrupted in Crohn's disease
E. Layunta, S. Javerfelt, F. C. van de Koolwijk, M. Sivertsson, B. Dolan, L. Arike, S. Thulin, B. A. Vallance, T. Pelaseyed
The paper identifies MUC17 as a critical component of the small intestinal glycocalyx that is disrupted in Crohn's disease, leading to bacterial contact and epithelial defects.
bioRxiv · Feb 8, 2024Physiology