Irreversible inhibition of TRF2TRFH recruiting functions: a strategy to induce telomeric replication stress in cancer cells.
A. P. Sobinoff, S. Di Maro, R. R. J. Low, R. Benedetti, S. Tomassi, A. D'Aniello, R. Russo, I. Baglivo, U. Chianese, P. V. Pedone, A. Chambery, A. J. Cesare, L. Altucci, H. A. Pickett, S. Cosconati
This paper identifies APOD53, a covalent cyclic peptide that irreversibly inhibits TRF2TRFH domain function, inducing telomeric replication stress and impairing cancer cell growth.
bioRxiv · Feb 1, 2023 · PreprintCancer Biology