Author

A. J. Cesare

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

V. P. Masamsetti· 3 shared A. P. Sobinoff· 2 shared H. A. Pickett· 2 shared J. Zhang· 2 shared T. K. Bartolec· 2 shared A. Braithwaite· 1 shared A. Chambery· 1 shared A. D'Aniello· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersCell Biology

V. P. Masamsetti

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Irreversible inhibition of TRF2TRFH recruiting functions: a strategy to induce telomeric replication stress in cancer cells.

A. P. Sobinoff, S. Di Maro, R. R. J. Low, R. Benedetti, S. Tomassi, A. D'Aniello, R. Russo, I. Baglivo, U. Chianese, P. V. Pedone, A. Chambery, A. J. Cesare, L. Altucci, H. A. Pickett, S. Cosconati

This paper identifies APOD53, a covalent cyclic peptide that irreversibly inhibits TRF2TRFH domain function, inducing telomeric replication stress and impairing cancer cell growth.

bioRxiv · Feb 1, 2023 · PreprintCancer Biology

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

C. B. Nelson, S. Rogers, K. Roychoudhury, Y. S. Tan, C. J. Atkinson, A. P. Sobinoff, C. G. Tomlinson, A. Hsu, R. Lu, E. Dray, M. Haber, J. I. Fletcher, A. J. Cesare, R. S. Hegde, H. A. Pickett

This study identifies PLK1 as a target of EYA4 and EYA1 phosphatases, showing that dephosphorylation of pY445 promotes PLK1 activation and mitosis, with implications for cancer therapy.

bioRxiv · Oct 10, 2022Cell Biology

Critical role for cold shock protein YB-1 in cytokinesis

S. Mehta, M. Algie, T. Al-Jabri, C. McKinney, S. Kannan, C. S. Verma, W. Ma, J. Zhang, T. K. Bartolec, V. P. Masamsetti, K. Parker, L. Henderson, M. Gould, P. Bhatia, R. Harfoot, , A. Braithwaite

This study identifies YB-1's role in cytokinesis by showing its necessity for microtubule organization and phosphorylation-dependent function.

bioRxiv · Mar 18, 2020Cell Biology

ATR and mTOR regulate F-actin to alter nuclear architecture and repair replication stress

N. Lamm, V. P. Masamsetti, M. N. Read, M. Biro, A. J. Cesare

bioRxiv · Nov 19, 2018Cell Biology

Phasor histone FLIM-FRET microscopy quantifies spatiotemporal rearrangement of chromatin architecture during the DNA damage response.

J. Lou, L. Scipioni, B. K. Wright, T. K. Bartolec, J. Zhang, V. P. Masamsetti, K. Gaus, E. Gratton, A. J. Cesare, E. Hinde

The paper develops a biophysical method to quantify chromatin compaction dynamics during DNA damage response using FLIM-FRET microscopy and identifies roles of ATM and RNF8 in chromatin reorganization.

bioRxiv · Sep 17, 2018Biophysics