R. Russo

Asymmetric Allostery in Estrogen Receptor-α Homodimers Drives Responses to the Ensemble of Estrogens in the Hormonal Milieu

This paper shows that estrogen receptor-α homodimers can function as conformational heterodimers, integrating different ligand signals to produce distinct agonist or antagonist activity profiles.

High-throughput optical sensing of peri-cellular oxygen in cardiac cells: system characterization, calibration, and testing

This paper develops and validates a high-throughput system for long-term optical measurement of peri-cellular oxygen in cardiac cells, showing dynamic oxygen changes and differences between hiPSC-CMs and fibroblasts.

Irreversible inhibition of TRF2TRFH recruiting functions: a strategy to induce telomeric replication stress in cancer cells.

This paper identifies APOD53, a covalent cyclic peptide that irreversibly inhibits TRF2TRFH domain function, inducing telomeric replication stress and impairing cancer cell growth.

Development of amidase-dependent pyrazinoic acid prodrugs with activity against pyrazinamide resistant Mycobacterium tuberculosis

This paper develops amidase-dependent pyrazinoic acid prodrugs that bypass PncA activation, showing efficacy against PZA-resistant Mtb.

A novel oral GyrB/ParE dual binding inhibitor effective against multidrug resistant Neisseria gonorrhoeae and other high-threat pathogens

The paper describes a novel oral inhibitor, JSF-2659, effective against multidrug-resistant Neisseria gonorrhoeae and other high-threat pathogens, with low potential for resistance development.

TRPV1 in arteries enables a rapid myogenic tone

This study identifies TRPV1 as essential for rapid myogenic tone in heart and skeletal muscle arteries, showing TRPV1 antagonists reduce tone and that TRPV1 mediates stretch-induced Ca2+ signaling and vasoconstriction.

TRPV1 expressed throughout the arterial circulation enables inflammatory vasoconstriction

This study identifies TRPV1 expression in vascular smooth muscle and demonstrates its role in inflammatory vasoconstriction and systemic blood pressure regulation.