Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection
K. S. Beckwith, M. S. Beckwith, S. Ullmann, R. S. R. Saetra, H. Kim, A. Marstad, S. E. Asberg, T. A. Strand, H. Stenmark, T. H. Flo
This study identifies a novel mechanism where plasma membrane damage during Mycobacterium tuberculosis infection triggers NLRP3-mediated pyroptosis and facilitates bacterial spread.
bioRxiv · Aug 28, 2019Immunology