H. Stenmark

Vesicle-mediated transport of ALIX and ESCRT-III to the intercellular bridge during cytokinesis

This study identifies vesicle-mediated transport of ALIX and ESCRT-III to the midbody during cytokinesis, showing microtubule-dependent motility and the role of kinesin-1 in this process.

"Double-Effect" strategy against Triple-Negative Breast Cancer via a synergistic therapy of Magneto-mechanical Force enhancing NIR-II Hypothermal Ablation

This paper develops a synergistic therapy for triple-negative breast cancer using magneto-mechanical force and NIR-II hypothermal ablation to suppress tumor migration and invasion.

Lysosome repair by ER-mediated cholesterol transfer

The paper identifies an ER-mediated cholesterol transfer mechanism for lysosome repair independent of ESCRTs, involving PI4K2A and OSBP.

ATPase activity of DFCP1 controls selective autophagy

This study identifies DFCP1 as an ATPase essential for omegasome constriction and selective autophagy by facilitating autophagosome release.

A phosphoinositide and RAB switch controls early macropinocytosis

This study identifies a phosphoinositide and RAB switch that regulates macropinosome fate between endolysosomal maturation and a secretory route.

Divalent ligand-monovalent molecule binding

The paper derives a general mathematical model for divalent ligand-monovalent molecule binding at any concentration ratio, showing the intermediate complex concentration is governed by a cubic equation.

Protein Crowding Mediates Membrane Remodeling in Upstream ESCRT-induced Formation of Intraluminal Vesicles

This study shows upstream ESCRTs mediate membrane deformation and ILV formation through crowding and altering bending rigidity, without requiring ATP.

JIP4 is recruited by the phosphoinositide-binding protein Phafin2 to promote recycling tubules on macropinosomes

This study identifies JIP4 and Phafin2 as components of a tubular recycling pathway from macropinosomes, showing JIP4 recruitment via Phafin2's PtdIns3P binding.

The phosphatidylinositol 3-phosphate binding protein SNX4 controls ATG9A recycling and autophagy

This study shows that SNX4 is required for ATG9A recycling from endolysosomes to early endosomes, which is essential for autophagic flux.

GAS6-AXL signaling triggers actin remodeling and macropinocytosis that drive cancer cell invasion

This study identifies GAS6-AXL signaling as a driver of cancer cell invasion through actin remodeling and macropinocytosis in glioblastoma cells under glutamine-deprived conditions.

Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection

This study identifies a novel mechanism where plasma membrane damage during Mycobacterium tuberculosis infection triggers NLRP3-mediated pyroptosis and facilitates bacterial spread.

Unrestrained ESCRT-III drives chromosome fragmentation and micronuclear catastrophe

This study shows that unrestrained ESCRT-III activity at micronuclei causes chromosome fragmentation and DNA damage, while it facilitates repair in primary nuclei.

Modulation of Secretory Lysosomes During NK Cell Education Leads to Accumulation of Granzyme B and Enhanced Functional Potential

This study shows that NK cell education leads to accumulation of granzyme B in secretory lysosomes, enhancing cytotoxic function through lysosomal Ca2+ signaling and TRPML1 regulation.

ESCRT-mediated lysosome repair precedes lysophagy and promotes cell survival

The paper shows ESCRT machinery repairs damaged lysosomes before lysophagy, promoting cell survival and aiding intracellular pathogens.