Cancer BiologybioRxivPreprint
1-deoxysphingolipid biosynthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells
T. Cordes, R. S. Kuna, G. H. McGregor…·C. M. Metallo
This study shows that 1-deoxysphingolipid synthesis, driven by SPT promiscuity, impairs anchorage-independent growth and plasma membrane endocytosis in cancer cells.
DOI 10.1101/2022.01.19.476986