Cell BiologybioRxiv
TopBP1 assembles nuclear condensates to switch on ATR signalling.
C. Frattini, A. Promonet, E. Alghoul…·A. Constantinou
This study shows TopBP1 forms condensates to activate ATR signaling, which phosphorylates Chk1 and slows replication forks.
DOI 10.1016/j.molcel.2020.12.049