Author

S.-L. Bekaert

Ghent University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

F. Speleman· 2 shared A. Claeys· 1 shared A. Eggermont· 1 shared Alexander M.M. EggermontiD· 1 shared Anna A. SablinaiD· 1 shared B. Hallberg· 1 shared C. Nunes· 1 shared C. Van Damme· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCancer Biology

F. Speleman

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Author profile →

3 papers

Recent·Most cited

5UTR translational inhibition of neuroblastoma dependency factors using the CR-1-31-B rocaglate

C. Nunes, S.-L. Bekaert, S. Parsa, Iris H. Nelen, F. Martens, Elisa de Stanchina, Ellen Sanders, Elien Hilgert, Sara T’Sas, P. Zhao, Fanny De Vloed, Alexander M.M. Eggermont, Steven Goossens, Anna A. Sablina, Lisa Depestel, , Kaat Durinck

This study evaluates CR-1-31-B's effects on neuroblastoma, showing reduced tumor growth and revealing translational inhibition of key dependencies and synergistic effects with CHK1 inhibition.

bioRxiv · Aug 29, 2024 · PreprintCancer Biology

Preclinical exploration of the DNA Damage Response pathway using the interactive neuroblastoma cell line explorer CLEAN.

J. Gabre, P. Merseburger, A. Claeys, J. Siaw, S.-L. Bekaert, F. Speleman, B. Hallberg, R. Palmer, J. Van den Eynden

The paper introduces CLEAN, a web tool for exploring neuroblastoma data, focusing on DNA damage response to identify drug targets.

bioRxiv · Sep 17, 2023Cancer Biology

The fork restart factor PHF6 interacts with RRM2 and binds to H3K56ac marked nascent DNA

L. Depestel, S.-L. Bekaert, E. Sanders, C. Van Damme, A. Eggermont, S. Loontiens, L. Tilleman, F. Van Nieuwerburgh, L. Delhaye, P. Van Vlierberghe, S. Eyckerman, F. Speleman, K. Durinck

This study identifies PHF6's interaction with RRM2 and its binding to H3K56ac marked nascent DNA, revealing a role in replication fork restart and DNA damage repair.

bioRxiv · Mar 8, 2023 · PreprintCancer Biology