P. Zhao

5UTR translational inhibition of neuroblastoma dependency factors using the CR-1-31-B rocaglate

This study evaluates CR-1-31-B's effects on neuroblastoma, showing reduced tumor growth and revealing translational inhibition of key dependencies and synergistic effects with CHK1 inhibition.

rarestR: An R package using rarefaction metrics to estimate α-diversity (species richness) and β-diversity (species shared) for incomplete samples

rarestR estimates α- and β-diversity for incomplete samples using rarefaction metrics and parametric extrapolations, offering visualization tools for curve fitting.

Increased dosage of wild-type KRAS protein drives KRAS-mutant lung tumorigenesis and drug resistance

This study shows that increased wild-type KRAS protein dosage in KRAS-mutant lung cancer drives tumor growth and drug resistance, with vascular changes mediated by mTOR pathway activation.

Arginine Di-methylation of RIPK3 Safeguards Necroptosis for Intestinal Homeostasis

This paper shows that arginine di-methylation of RIPK3 by PRMT5 prevents necroptosis in intestinal epithelial cells, maintaining homeostasis and preventing disease.

Unraveling wheat endosperm development: epigenetic regulation and novel regulators for enhanced yield and quality

This study identifies novel regulators of starch and seed storage protein biosynthesis in wheat endosperm, revealing their role in grain yield and quality through epigenetic and transcriptional mechanisms.

TaNF-Y-PRC2 orchestrates temporal control of starch and protein synthesis in wheat

This study identifies the TaNF-Y-PRC2 complex as a regulator of starch and protein synthesis in wheat endosperm, revealing its role in epigenetic control through histone modification and gene repression.

Biosynthesis of the proteins containing neurotoxin β-N-methylamino-L-alanine in marine diatoms

This study investigates how iron limitation increases BMAA-containing protein production in marine diatoms and identifies cysK as a key enzyme in BMAA biosynthesis.

Millimeter-scale magnetic implants paired with a fully integrated wearable device for wireless biophysical and biochemical sensing

This paper develops magnetic implants paired with a wearable device to wirelessly measure biophysical and biochemical signals in rats.

TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2/HIF-1alpha axis in melanoma

This study shows TIPE promotes glycolysis and stemness in melanoma by interacting with PKM2 and activating HIF-1α through phosphorylation.

Rationale design of unrestricted pRN1 derivatives and their application in construction of a dual plasmid vector system for Saccharolobus islandicus

The paper designs mutated pRN1 plasmid backbones to evade CRISPR immunity in Saccharolobus islandicus, enabling stable plasmid vectors and a dual plasmid system for genetic studies.

An eco-physiological model of forest photosynthesis and transpiration under combined nitrogen and water limitation

The paper develops an eco-physiological model to predict combined effects of water and nitrogen limitations on forest growth using optimality principles and validates it with field measurements.

Inflammation-Induced Claudin-2 Upregulation Limits Pancreatitis Progression by Enhancing Tight Junction-Controlled Pancreatic Ductal Transport

This study shows CLDN2 upregulation during pancreatitis limits disease progression by enhancing tight junction-controlled fluid transport in pancreatic ductal epithelium.

TIPRL1 and its ATM-dependent phosphorylation promote radiotherapy resistance in head and neck cancer

This study identifies TIPRL1 and its ATM-dependent phosphorylation as contributors to radiotherapy resistance in head and neck cancer by modulating DNA damage response.

Promotion of tumor angiogenesis and growth induced by low-dose antineoplastic agents via bone-marrow-derived cells

This study investigates low-dose antineoplastic agents' effects on tumor growth and angiogenesis via bone-marrow-derived cells in mouse models.

Computational repurposing of oncology drugs through off-target drug binding interactions from pharmacological databases

This paper presents a computational method to identify off-target drug binding interactions for oncology drug repurposing using pharmacological databases and clinical data.

Structure of a fungal 1,3-β-glucan synthase

This study determines the cryo-EM structure of Saccharomyces cerevisiae 1,3-β-glucan synthase Fks1, revealing its catalytic mechanism and the role of disulfide bonds in enzymatic activity.

PD1 is transcriptionally regulated by LEF1 in mature T cells

This study shows LEF1, not TCF1, regulates PD1 transcription in mature T cells, with implications for cancer immunotherapy.

m6A Demethylase FTO Stabilizes LINK-A to Exert Oncogenic Roles via MCM3-Mediated Cell Cycle Progression and HIF-1α Activation

This study shows FTO stabilizes LINK-A, promoting ESCC progression through MCM3-mediated cell cycle progression and HIF-1α activation.

Prospective isolation according to melanin pigment content of melanoma cells with heterogeneous potentials for disease propagation

This study isolates melanoma cells based on melanin content, finding that low-pigment cells are more abundant and have higher tumorigenic potential than high-pigment cells.

Contact Stiffness Provides a Unified Frame of Reference for Understanding the Effects of Extracellular Matrix Mechanics on Cell Behaviors

The paper introduces contact stiffness as a framework to quantify how ECM mechanics influence cell behaviors, showing its correlation with YAP activity and stem cell differentiation.

Sequential in vitro enzymatic N-glycoprotein modification reveals site-specific rates of glycoenzyme processing

The paper investigates site-specific rates of glycan processing in vitro and finds that local structural factors influence enzymatic modification efficiency and microheterogeneity.

HCP5 prevents ubiquitination-mediated UTP3 degradation to inhibit apoptosis by activating c-Myc transcriptional activity

This study identifies HCP5 as a key antiapoptotic factor in ESCC by preventing UTP3 degradation and activating c-Myc to suppress apoptosis.

Population Transcriptome and Phenotype Reveal that Rht-D1b Contributes a Larger Seedling Root to Modern Bread Wheat

The paper investigates the impact of GR alleles on wheat root systems, finding that Rht-D1b increases seedling root size by enhancing cell length and meristem size, while Rht-B1b has no significant effect on root traits.

The peptide GOLVEN10 controls nodule and lateral root organogenesis and positioning along the longitudinal root axis

The paper identifies GOLVEN10 peptide as a regulator of nodule and lateral root positioning and organogenesis in Medicago truncatula.

Tracing the substrate translocation mechanism in P-glycoprotein

This study reveals the substrate translocation mechanism in P-glycoprotein by determining cryoEM structures and using molecular dynamics simulations to identify conformational changes in TM1 that regulate transport.

DLGAP1-AS2-Mediated Phosphatidic Acid Synthesis Confers Chemoresistance via Activation of YAP Signaling

This study identifies D-AS2 as a noncoding RNA that promotes chemoresistance in SCC by activating YAP signaling through the PLD/PA axis, and shows that targeting D-AS2 sensitizes SCC to cisplatin.

Cytosolic EZH2-IMPDH2 complexes regulate melanoma progression via GTP

This paper identifies a non-canonical, methyltransferase-independent mechanism by which EZH2 promotes melanoma progression through interactions with IMPDH2 and GTP synthesis.

Inhibition of sodium conductance by cannabigerol contributes to a reduction of neuronal dorsal root ganglion excitability

This study investigates how CBG inhibits Nav channels in DRG neurons and shows it reduces excitability through state-dependent inhibition and functional selectivity.

RAMPs regulate signalling bias and internalisation of the GIPR

This study shows RAMPs modulate GIPR signaling and internalization, with RAMP3 reducing cAMP production and promoting surface retention, while RAMP1/2 decrease Gq/11/15 activation, and RAMP1 is essential for normal glucose regulation.

Loss of STAT5 in adipocytes increases subcutaneous fat mass via sex-dependent and depot-specific pathways

This study shows that loss of STAT5 in adipocytes leads to increased subcutaneous fat mass, with sex- and depot-specific effects on fat cell size and insulin resistance.