Sadik Esener

The paper uses methylation patterns in the protocadherin gene cluster to track clonal dynamics across human tissues over time, revealing subclonal architectures and cryptic expansions not detectable by standard mutation sequencing.

The paper tracks DNA methylation changes in blood samples up to 15 years before AML diagnosis, identifying DMRs linked to clonal expansions and epigenetic reprogramming.

This paper introduces a minimally invasive coaxial microprobe for multi-modal neural interfacing, enabling efficient electrical and optical interrogation with reduced inflammation.