Author

Sam Sabaat

University of California, Berkeley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Cherise Stanley· 1 shared Chris H. Habrian· 1 shared Colin D. Kinz-ThompsoniD· 1 shared Connor LudwigiD· 1 shared Daniel K. NomuraiD· 1 shared Ehud Y. IsacoffiD· 1 shared Henry ChaniD· 1 shared Julia BleieriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiophysics

Cherise Stanley

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2 papers

Recent·Most cited

Covalent Modulators of Immune Regulatory Transcription Factors IRF8 and IRF5

Thang Do Cong, Henry Chan, Justin Greene, Sam Sabaat, Connor Ludwig, Nathan S. Abell, Matthew L. Albert, Sriram Kosuri, Daniel K. Nomura

This paper identifies covalent modulators that target and degrade IRF5 and IRF8, key inflammatory transcription factors, with TH-B10 showing potent and selective degradation of IRF8.

bioRxiv · Aug 3, 2025 · PreprintBiochemistry

Domain coupling in activation of a family C GPCR

Naomi R. Latorraca, Sam Sabaat, Chris H. Habrian, Julia Bleier, Cherise Stanley, Colin D. Kinz-Thompson, Susan Marqusee, Ehud Y. Isacoff

This study identifies a pre-active intermediate in GPCR activation and shows how dimer interactions influence signaling efficacy and functional diversity.

Nature Chemical Biology · Apr 25, 2025Peer-reviewedBiophysics