Susan Marqusee

This study identifies nucleosome core allostery as a mechanism that amplifies minimal variations in nucleosomes to influence chromatin accessibility and cell fate.

This study uses a hydrogen-deuterium pulse-labeling approach to reveal structural details of nascent polypeptide folding during translation and its kinetic coupling with translation.

This study identifies an allosteric mechanism in eIF2B that regulates the Integrated Stress Response by showing how eIF2-P binding inhibits eIF2B activity through latch-helix dislocation.

The paper describes the structure and function of a membrane-spanning E3 ubiquitin ligase complex, revealing its role in developmental processes and linking mutations to human birth defects.

This study compares the energy landscapes of two subtilisins, ISP1 and SbtE, showing how their pro-domains affect stability and dynamics.

This study identifies a pre-active intermediate in GPCR activation and shows how dimer interactions influence signaling efficacy and functional diversity.

This paper identifies how Nub1 traps unfolded FAT10 for ubiquitin-independent degradation by the 26S proteasome through a novel mechanism involving structural dynamics and proteasomal engagement.

This study identifies a partially unfolded N-terminal domain intermediate in cataract-associated γD-crystallin variants under native conditions, revealing hydrophobic patches that may contribute to cataract formation.

The paper analyzes SARS-CoV-2 spike protein dynamics using eVLPs and HDX-MS, showing the D614G mutation and furin cleavage influence conformational states and infectivity.

This study investigates how circular permutation affects protein folding and aggregation in HaloTag, finding that termini placement in flexible regions is more critical than proteostasis factors.

The paper proposes a step-wise activation model for metabotropic glutamate receptor subtype 5, supported by structural and fluorescence imaging data of different activation states.

The paper compares consensus and ancestral protein reconstruction methods using Ribonuclease H sequences, finding that phylogenetically restricted consensus proteins are more stable than those from diverse clades.