Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues
Kimberley M. Mellor, Upasna Varma, Parisa Koutsifeli, Claire L. Curl, Johannes V. Janssens, Lorna J. Daniels, Gabriel B. Bernasochi, Antonia J. A. Raaijmakers, Marco Annandale, X. Li, Samuel L. James, DAVID J. TAYLOR, Koen Raedschelders, Kate L. Weeks, Richard J. Mills, , Lea M.D. Delbridge
This study identifies glycophagy dysregulation as a mechanism of diabetic heart disease and shows that Gabarapl1 gene therapy improves cardiac function in diabetic mice and human cardiac organoids.
Nature Cardiovascular Research · Sep 29, 2025Peer-reviewedPhysiology