Author

Samuel O'Brien

Georgetown University

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Biology Disciplines

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Bioinformatics· 1

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Research Focus:benchmarking· 1 Approach:contrastive learning· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

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Eliot KmieciD· 1 shared Matthew McCoyiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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1 paper

Recent·Most cited

BioinformaticsbioRxivPreprintMay 16, 2026

Hidden State Genomics: Graph-Based Analysis of Sparse Auto-Encoder Feature Activity in Genomic Language Models

Eliot Kmiec, Samuel O'Brien, Matthew McCoy

The paper investigates genomic language model representations by analyzing sparse auto-encoder features, finding they encode granular sequence syntax and conservation patterns rather than complex regulatory logic.

DOI 10.64898/2026.05.13.725007

DNA methylationwhole-genome sequencing

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