Molecular BiologyCellPeer-reviewed
The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells
Markus Hoffmann, Hannah Kleine‐Weber, Simon Schroeder…·Stefan Pöhlmann
The paper shows that 2019-nCoV uses ACE2 and TMPRSS2 for cell entry, identifies TMPRSS2 as a therapeutic target, and demonstrates neutralization by SARS patient serum.
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