NeuroscienceJournal of NeurosciencePeer-reviewed
Human iPSC-derived microglia sense and dampen hyperexcitability of cortical neurons carrying the epilepsy-associated SCN2A-L1342P mutation
Zhefu Que, Maria I. Olivero-Acosta, Morgan J. Robinson…·Yang Yang
This study shows human iPSC-derived microglia detect and reduce hyperexcitability in neurons with the SCN2A-L1342P epilepsy mutation through morphological and calcium changes and reduced sodium channel current density.
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