NR4A1 limits CD8⁺ T Cell effector responses and protection in tuberculosis
Amit Singhal, Samreen Fatima, Yao Chen, Lorissa Smulan, Basanthi Satish, Mike Jameson, Sheetal Saini, Calvin Johnson, Alicia Tay, Shihui Foo, Hedayathulla Rahmathulla, Akhila Balachander, Shanshan Wu Howland, Hardy Kornfeld
NR4A1 suppresses CD8+ T cell infiltration and cytotoxicity in TB lesions, and its inhibition enhances host resistance to Mtb infection.
bioRxiv · Jan 13, 2026 · PreprintImmunology