Yao Chen

RBP4-BACH1 Interaction Modulates Transcriptional Regulation of Insulin Signaling Pathway Genes

This study identifies RBP4-BACH1 interaction as a regulator of insulin signaling pathway genes, linking circadian disruption to glucose metabolism dysregulation.

NR4A1 limits CD8⁺ T Cell effector responses and protection in tuberculosis

NR4A1 suppresses CD8+ T cell infiltration and cytotoxicity in TB lesions, and its inhibition enhances host resistance to Mtb infection.

Neonatal BCG Vaccination Engages the Vasculature to Elicit γδ T Cell-Mediated Protection against Tuberculosis

This study shows neonatal BCG vaccination expands IL-17/IL-22-producing γδ T cells, mediates protection against TB, and induces a microbiome signature linked to gut-lung axis immunity.

AAV-mediated ARSA replacement for the treatment of Metachromatic Leukodystrophy

This study develops an AAV vector for ARSA gene replacement in MLD, showing improved brain biodistribution and therapeutic effects in mice and non-human primates.

Glial state changes and neuroinflammatory RIPK1 signaling are a key feature of ALS pathogenesis

This study identifies glial state changes and RIPK1 signaling as key features of ALS pathogenesis, showing that blocking RIPK1 delays disease onset and modulates glial responses.

Meiosis related cancer-testis genes correlate with tumor aneuploidy and immune infiltration in 21 cancer types

The paper investigates the correlation between meiosis-related cancer-testis genes, tumor aneuploidy, and immune infiltration across 21 cancer types using multi-omics data.

Genome-wide CNV study and functional evaluation identified CTDSPL as tumour suppressor gene for cervical cancer

The paper identifies a deletion in CTDSPL as a strong genetic risk variant for cervical cancer, showing it suppresses tumor growth in vitro and in vivo.