Molecular BiologybioRxivPreprint
Single Amino Acid Disease Mutations Act as Genetic Glues to Drive Neo-substrate Degradation
Baiyun Wang, Chi-Wei Yeh, Hsuan-Mei Lin…·Hsueh-Chi Sherry Yen
The paper identifies single amino acid mutations that create functional degrons in transcription factors, enabling targeted protein degradation and revealing a new mechanism for disease-related protein turnover.
DOI 10.64898/2026.09.17.752235