Cancer BiologybioRxivPreprint
High glucose confers senescence resistance via GLUT1 epigenetic rewiring to blunt immunotherapy responses in esophageal squamous cell carcinoma
Jinxiu Dong, Jie Zhou, Jia‐Jie Hao…·Yan‐Yi Jiang
This study identifies GLUT1 as a driver of immunotherapy resistance in ESCC by epigenetically suppressing senescence and reveals dietary glucose restriction as a potential strategy to enhance immunotherapy efficacy.
DOI 10.64898/2026.07.15.738372