Molecular Glue-Induced Homodimerization Drives Targeted CRBN Autodegradation
Lu Chen, Xiaoxiao Zou, Jiayin Liang, Jun Wang, Xiaolin Luo, Taiting Shi, Xinzhu Li, Shuke Yang, Linhui Cao, Yingjie Sun, Yue Zhao, Hewei Jiang, Yi Jiang, Zhipeng Su, Huan Xiong, , Wenchao Lu
This paper introduces LJY-3-60, a molecular glue that induces CRBN homodimerization and autodegradation, providing a tool for controlled protein degradation.
bioRxiv · Mar 10, 2026 · PreprintBiochemistry